4-Aminoquinolines as Antimalarial Agents: Review of A Medicinal Chemistry Perspective

Abstract: Malaria is a potentially fatal parasitic disease brought on by five Plasmodium species, including falciparum, vivax, ovale, malariae, and knowlesi. The fast emergence of P. falciparum resistance to currently available treatments has increased health concerns in developing countries. growth emphasizes the need for novel, secure, cost-effective antimalarial drug that can treat malaria resistant multiple drugs. Therefore, it become crucial create new therapeutic approaches deal with rise parasites artemisinin. For treatment children living areas moderate high transmission, as established WHO, vaccine RTS, S been authorized. WHO recommends governments consider this immunization against human parasite when deciding optimum subnational combination measures maximum impact. current research synthesizes numerous 4-aminoquinoline derivatives successfully treating its diverse etiological species. Additionally management prevention are antibiotics. Effective well-tolerated medications include tetracycline chloramphenicol, chloroquine, primaquine, pamaquine, artemisinins some drugs used malaria; however, compounds have proven be even more efficient. This review, based literature reports, will give medicinal chemists ideas develop. In addition, review help search leads future.